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KMID : 1022820210120020043
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Journal of Multiple Sclerosis and Neuroimmunology
2021 Volume.12 No. 2 p.43 ~ p.46
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Recurrent Hypertrophic Pachymeningitis Successfully Treated with Cyclophosphamide
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Eom Hyun-Jong
Kim Min-Kyung
Shin Ji-Hye
Kim Ji-Hyun
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Abstract
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Hypertrophic pachymeningitis is a inflammatory disorder that causes fibrous thickening of the dura mater, presenting with headache, diplopia, focal deficit, and seizure. High-dose corticosteroid is generally accepted as the first-line treatment. Some cases were reported to be refractory to corticosteroid, and immunosuppressive drugs lead to clinicoradiologic resolution in such cases. Herein, we reported a patient with relapsing idiopathic hypertrophic pachymeningitis in whom neurological symptoms and radiological abnormalities were refractory to corticosteroids and were successfully reversed with cyclophosphamide treatment.
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KEYWORD
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Idiopathic hypertrophic pachymeningitis, Methylprednisolone, Cyclophosphamide
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